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Amylyx Pharmaceuticals Raises $30 Million in Series B Funding July 1, 2020

– Proceeds enable continued investment in lead product candidate AMX0035 in ALS and Alzheimer’s disease – Amylyx has closed more than $45M in financing in 2020 Amylyx Pharmaceuticals, Inc., a pharmaceutical company focused on developing new treatments for amyotrophic lateral sclerosis (ALS), Alzheimer’s disease and other neurodegenerative diseases, today announced it has closed an oversubscribed $30 million Series B financing, led by Morningside Ventures, with participation from other investors. “The results AMX0035 achieved for ALS patients in the CENTAUR trial paired with Amylyx’ strong partnerships in the ALS and Alzheimer’s communities give credence to continued success,” said Isaac Cheng, M.D., of Morningside Ventures. “By targeting mitochondrial and endoplasmic reticulum dependent neuronal degeneration pathways, Amylyx can have a very significant impact for patients suffering from neurodegenerative diseases, a critical threat to global public health.” “We share Morningside’s

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Amylyx Pharmaceuticals Announces Completion of Enrollment in the PEGASUS Trial of AMX0035 in Alzheimer’s Disease June 15, 2020

– Amylyx Remains on Track to Share Topline PEGASUS Trial Results by Q1 2021 Amylyx Pharmaceuticals, Inc., a pharmaceutical company focused on developing new treatments for amyotrophic lateral sclerosis (ALS), Alzheimer’s disease and other neurodegenerative diseases, today announced it has completed enrollment in the Phase II PEGASUS trial assessing AMX0035 in individuals with Alzheimer’s disease. Amylyx completed enrollment, dosing 96 of the previously planned 100 participants. The PEGASUS trial will provide data on the safety and tolerability profile of AMX0035 in people living with Alzheimer’s disease, biological activity on biomarkers related to disease processes and preliminary information on cognitive and functional effects of AMX0035. Trial collaborators include the Alzheimer’s Association, the Alzheimer’s Drug Discovery Foundation (ADDF) and Cure Alzheimer’s Fund. In April 2019, Amylyx doubled the PEGASUS trial’s planned enrollment to approximately 100 participants with

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Machelle Manuel, Ph.D., Joins Amylyx Pharmaceuticals as Vice President, Head of Global Medical Affairs May 11, 2020

New Vice President of Medical Affairs Brings 20+ Years of Experience to Growing Leadership Team Amylyx Pharmaceuticals, Inc., a pharmaceutical company focused on developing new treatments for amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, today announced the appointment of Machelle Manuel, Ph.D., as Vice President, Head of Global Medical Affairs. Dr. Manuel brings more than 20 years of experience in medical scientific affairs in the pharmaceutical industry. “It is our great pleasure to welcome Dr. Manuel to Amylyx as we continue our quest to end suffering caused by neurodegenerative diseases,” said Patrick Yeramian, M.D., MBA, Chief Medical Officer at Amylyx Pharmaceuticals. “Machelle brings an impressive and unique skillset and leadership qualities that will further poise Amylyx to grow from a clinical- to commercial-stage company.” Previously, Dr. Manuel spent eight years at Ironwood Pharmaceuticals, where she was head of global medical scientific affairs

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