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Determining Individual Substantial Response in Amyotrophic Lateral Sclerosis: Utilizing a New Method on CENTAUR Trial Results

Lead Author: Tracey Jason, PhD, Head of Medical Affairs at Amylyx Pharmaceuticals Canada

Published: Canadian Neurological Sciences Federation (CNSF)

Date: June 26, 2022

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Determining Individual Substantial Response in Amyotrophic Lateral Sclerosis: Utilizing a New Method on CENTAUR Trial Results

Lead Author: Lahar Mehta, MD, Head of Global Clinical Development at Amylyx Pharmaceuticals

Published: European Network to Cure ALS (ENCALS)

Date: June 2, 2022

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Effect of Sodium Phenylbutyrate/Taurursodiol on Tracheostomy/Ventilation-Free Survival and Hospitalisation in Amyotrophic Lateral Sclerosis: Long-Term Results from the CENTAUR Trial

Lead Author: Sabrina Paganoni, MD, PhD

Published: Journal of Neurology, Neurosurgery and Psychiatry

Date: May 16, 2022

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Survival Analyses from the CENTAUR Trial in Amyotrophic Lateral Sclerosis: Evaluating the Impact of Treatment Crossover on Outcomes

Lead Author: Sabrina Paganoni, MD, PhD

Published: Muscle & Nerve

Date: May 4, 2022

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Safety of a Fixed-Dose Coformulation of Sodium Phenylbutyrate and Taurursodiol in Amyotrophic Lateral Sclerosis and Alzheimer's Disease: Integrated Clinical Trial Experience

Lead Author: Steven E. Arnold, MD

Published: American Academy of Neurology (AAN)

Date: April 4, 2022

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Expanded Access to Sodium Phenylbutyrate/Taurursodiol Coformulation in Amyotrophic Lateral Sclerosis: Learnings From an ALS Community Partnership

Lead Author: Machelle Manuel, PhD, Head of Global Medical Affairs at Amylyx Pharmaceuticals

Published: Muscular Dystrophy Association (MDA)

Date: March 13 - 16, 2022

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Global Phase 3, Randomized, Placebo-Controlled Trial of a Fixed-Dose Coformulation of Sodium Phenylbutyrate and Taurursodiol in Amyotrophic Lateral Sclerosis (A35- 004 PHOENIX): Study Design Overview

Lead Author: Leonard H. van den Berg, MD, PhD

Published: International Symposium on ALS-MND (MNDA)

Date: December 8, 2021

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Long-Term Functional Benefits and Safety of a Fixed-Dose Coformulation of Sodium Phenylbutyrate and Taurursodiol in Amyotrophic Lateral Sclerosis

Lead Author: Sabrina Paganoni, MD, PhD

Published: International Symposium on ALS-MND (MNDA)

Date: December 7, 2021

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Safety and Biological Activity of a Fixed-Dose Coformulation of Sodium Phenylbutyrate and Taurursodiol (PB/TURSO) for the Treatment of Alzheimer's Disease: Results from the Phase 2a PEGASUS Study

Lead Author: Steven E. Arnold, MD

Published: Clinical Trials on Alzheimer’s Disease (CTAD)

Date: November 9 - 12, 2021

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Longer Overall Survival in the CENTAUR Trial: A Rank-Preserving Structural Failure Time Model Adjusts for Crossover From Placebo to Sodium Phenylbutyrate (PB)/Taurursodiol (TURSO)

Lead Author: Sabrina Paganoni, MD, PhD

Published: Northeast ALS Consortium Annual Meeting (NEALS)

Date: October 7, 2021

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