Science


MECHANISM OF DISEASE

Recent progress in the understanding of neurodegenerative diseases revealed that multiple molecular mechanisms contribute to pathological changes in neurons. A large fraction of these alterations can be linked to biochemical dysfunction in the endoplasmic reticulum (ER) and mitochondria — physically and functionally interconnected via mitochondrial-associated membranes (MAM), which participate in Ca2+ signaling, lipid transport, energy metabolism and cell survival. Apart from their vital physical association coordinating pathways involved in cell life and death, any loss of communication in them complicates and worsens the prevailing conditions in neurodegenerative diseases like ALS and Alzheimer’s disease.

 

INSIDE ALS: THE NEURONS BEHIND THE DISEASE

Learn how endoplasmic reticulum and mitochondrial dysfunctions contribute to ALS pathophysiology.

Additional Resources Relevant Trials

Webinars

Amylyx webinars present information to you on many topics related to ALS and other neurodegenerative diseases. Browse our library of on-demand webinars below.

LONG-TERM SURVIVAL RESULTS FROM THE CENTAUR TRIAL

An overview of the long-term survival analysis of AMX0035 in people with Amyotrophic Lateral Sclerosis (ALS).

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