Our beginnings were defined by an unconventional approach to making a difference. It’s a belief that drives our work forward, strengthens our connections and continues to push the boundaries of what’s possible. We are not delegators, procrastinators or nay-sayers. We’re a group of get-it-done problem solvers who never hesitate to question the obvious.

Working At Amylyx

Amylyx is a place where you can apply your intellect and experience in ways you’ve never done before. We’re inspired by uncommon perspectives and learning from collective experiences. Our team thrives within the unconventional, allowing our processes to inform but never stand in the way of progress.  

We’re looking for mission-driven builders and collaborative self-starters who can roll their sleeves up in the interest of making a collective difference. If that sounds like you, let’s talk.


We care deeply about the people with whom we work and have structured our benefits to connect them with support in every facet of their lives. Because when you’re at your best, we’re at ours.

  • Flexible work environment
    • We want to ensure Amylyx is an organization that allows you to do your best work, wherever and whenever that is. That’s why each of our employees has the opportunity to telecommute in a way that works best for all of us.
  • Discretionary time off
    • We think it’s important for team members to take time off when they need it. We offer uncapped time off with no set number of vacation days.
  • Comprehensive healthcare coverage
    • Our programs ensure you have robust coverage. We offer a PPO (Preferred Provider Organization) medical plan and an HMO (Health Maintenance Organization).  Our PPO plan is paired with an HSA (Health Savings Account) in which Amylyx contributes 50% of the PPO deductible. We also offer dental benefits for our employees and their families.
  • 100% Company Paid Life and Disability Insurance
    • We provide full coverage for life insurance and short- and long-term disability coverage to help care for employees and families.
  • Other Benefits
    • Paid Parental Leave
    • Employee Assistance Program
    • Commuter Benefits

Our Values

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Be Audacious

Patients are our true north; we envision new possibilities, boldly seek untried approaches and fearlessly innovate for them.

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Be Curious

By asking the right questions, listening and learning, we thrive in a culture of continuous improvement, driven by generously sharing knowledge, making each of us, and the company, better.

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Be Engaged

We can only understand patients’ needs when we understand their journey. By deeply engaging the patient and care provider communities, we know what’s needed.

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Be Accountable

Patients are waiting; they come first, and we have a responsibility to turn our most promising ideas into urgent action on their behalf.

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Be Authentic

When we genuinely care about the work we do and the people with whom we work, we make Amylyx a place where breakthroughs for patients are possible.

Open Positions


Head of Quality ComplianceApply
  • Cambridge, MA

Amylyx is seeking a Head of Compliance who will be responsible for developing, maintaining, and executing Quality Management Systems (QMS) and processes to ensure GxP compliance. We are looking for a hands-on individual that can partner with internal departments to develop and support the Documentation Management System (DMS), Learning Management System (LMS) and Quality Management System (QMS) process improvement implementations that meet business and regulatory requirements. The individual will lead inspection readiness activities to assure Amylyx is inspection ready at all times. The individual will also be responsible for supplier oversite and audit execution.


Head of Global Clinical OperationsApply
  • Cambridge, MA

In this newly created role, you will join a clinical team dedicated to developing treatments to slow the progression of neurodegenerative diseases including Amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease. In this hands-on role, you will manage all operational aspects of clinical development projects, provide project leadership and program oversight to plan and conduct one or more high-quality clinical trials concurrently, in accordance with FDA, CFR, EMA, and ICH GCP regulations and have primary responsibility for achievement of key progress milestones related to trial operations US and ex-US.


If you’re here, our mission is most likely aligned with yours. Please feel free to reach out with any questions or requests for information.

Contact Us

Pegasus Alzheimer’s Trial

PEGASUS is a 3:2 randomized, double-blind, multi-center, placebo-controlled trial evaluating the safety, tolerability and activity of AMX0035 in patients with late mild cognitive impairment or early dementia due to Alzheimer’s disease over 24 weeks.

More Information

Listen to Josh Cohen, Co-CEO and Co-Founder and Justin Klee, Co-CEO and Co-Founder talk about Amylyx' origin story and hope for the future for ALS and Alzheimer's disease patients.

Listen to Podcast